What’s Causing Your Memory Loss? - HelpGuide.org (2023)

Adapted with permission fromAlzheimer's Disease: A guide to diagnosis, treatment, and caregiving, a special health report published byHarvard Health Publishing.

What else can cause memory loss

More than 50 conditions can cause or mimic the symptoms of dementia, and a small percentage of dementias are reversible. Two common examples are dementia caused by vitamin B12 deficiency or an underactive thyroid (hypothyroidism). Getting the right diagnosis is important so that you know what options you have, because symptoms subside when the underlying problem is treated.

Distinguishing between types of dementia

For physicians and families intent on pinning down a diagnosis, one major complicating factor is the existence of so many kinds of dementia. More than 50 conditions can mimic or cause dementia.

Alzheimer’s disease is by far the most common intractable condition. But other causes of irreversible dementia include blood vessel disease vascular dementia), other degenerative disorders (frontotemporal lobar degeneration, Parkinson’s disease, Huntington’s disease), slow-growing brain tumors, or infections of the central nervous system (Creutzfeldt-Jakob disease, AIDS dementia, neurosyphilis).

In some types of dementia, treatment will improve mental functioning, and in a small percentage, the dementia is completely reversible if treatment begins before permanent brain damage occurs. That’s why it is important to report to a doctor any signs of dementia as early as possible.


The world's largest therapy service. 100% online. Get matched with a professional, licensed, and vetted therapist in as little as 48 hours.

Get 20% off

(Video) BCH Lecture: Memory Loss: What’s Normal, What’s Not?

Reversible dementias

Reversible dementias are often easier to diagnose than irreversible dementias because they are usually accompanied by other, obvious symptoms. In the following conditions or situations, however, dementia may be the primary, or even the only, symptom. Proper treatment may improve or even restore cognitive functioning.


Delirium causes changes in mental functioning that can closely resemble dementia, but there are two important differences:

  • Speed of onset. The mental changes in delirium develop quickly, often in a matter of hours or days. In contrast, dementia evolves over months or years.
  • Level of consciousness. In delirium, consciousness is either clouded or fluctuates between drowsiness and alertness. Dementia doesn’t affect the level of consciousness.

Delirium is considered a medical emergency, in part because it’s often the main expression of a sudden, life-threatening illness. Elderly people are also susceptible to delirium after surgery.

Alcohol withdrawal syndrome presents the classic picture of delirium. Similarly, delirium can occur from abrupt withdrawal from benzodiazepines, a group of anti-anxiety drugs that includes diazepam (Valium), chlordiazepoxide (Librium), and alprazolam (Xanax).

Toxic reactions to drugs

Medications are common culprits in mental decline. With aging, the liver becomes less efficient at
metabolizing drugs, and the kidneys eliminate them from the body more slowly. As a result, drugs tend to
accumulate in the body. Elderly people in poor health and those taking several different medications are
especially vulnerable.

The list of drugs that can cause dementia-like symptoms is long. It includes:

  • antidepressants
  • antihistamines
  • anti-Parkinson drugs
  • anti-anxiety medications
  • cardiovascular drugs
  • anticonvulsants
  • corticosteroids
  • narcotics
  • sedatives


People sometimes manifest dementia-like symptoms—forgetfulness, disorientation, inattentiveness, and slowed responses—when they are depressed. This so-called pseudodementia can masquerade as the depression that often accompanies Alzheimer’s disease, but there are subtle differences.

  • Pseudodementia. In pseudodementia, the depressed mood begins before there is any mental decline. Typically, the person complains about memory loss or lack of concentration, looks sad or worried, and speaks in a flat, expressionless tone.
  • Depression. In Alzheimer’s-related depression, the mental decline comes first, and the person usually tries to conceal memory problems, rather than call attention to them.

Vitamin B12 deficiency

What’s Causing Your Memory Loss? - HelpGuide.org (2)

In older people, the first symptoms of pernicious anemia are often confusion, slowness, irritability, and apathy. Other symptoms of pernicious anemia include:Dementia could be a symptom of pernicious anemia, a rare condition caused by low levels of vitamin B12. In people with pernicious anemia, the bone marrow produces red blood cells that are both larger and less numerous than normal (see illustration).

  • yellowish skin
  • fatigue
  • shortness of breath
  • headaches
  • numbness or tingling in the hands and feet
  • trouble keeping balance

Usually the B12 deficiency that underlies pernicious anemia is not caused by a lack of B12 in the diet. That’s because this vitamin is plentiful in eggs, dairy products, meat, fish, and poultry, and it’s efficiently stored in the liver.

Instead, a B12 deficiency usually occurs because an individual can’t absorb the vitamin from food. Fortunately, B12 injections, if started early, can remedy the deficiency and alleviate the symptoms of pernicious anemia.

(Video) 21 Signs You’re Experiencing “Soul Loss”


Hydrocephalus (“water on the brain”) is an excess of cerebrospinal fluid around the brain. The fluid is secreted by the ventricles (cavities in the center of the brain). It circulates around the spinal cord and is absorbed by veins on the external surface of the brain.

Congenital hydrocephalus is usually diagnosed shortly after birth, but normal-pressure hydrocephalus occurs in a small number of elderly people. This condition can result from head trauma, brain hemorrhage, or meningitis (inflammation of the membrane covering the brain), but most cases occur spontaneously without an obvious preceding illness.

In addition to developing dementia, people with this condition lose bladder control and walk in a slow, hesitant manner, as if their feet are stuck to the floor. A surgically implanted tube (shunt) that drains fluid from a cavity in the brain (the lateral ventricle) to the jugular vein or to the abdomen brings rapid improvement, provided treatment is started soon after the symptoms appear.


Brain tumors may be malignant (cancerous) and therefore capable of invading surrounding tissue. Or they may be benign (self-contained).

Brain tumors can interfere with cognitive functioning and cause personality changes. Depending on their location, they can trigger other symptoms, such as headaches, seizures, or vomiting.

The first symptoms of slow-growing tumors frequently resemble dementia, especially in older people.

Subdural hematomas

Hematomas are blood clots caused by bruising. When they are located in the subdural area, between the brain surface and the thin membrane that covers it (the dura), they can cause symptoms that mimic Alzheimer’s disease. Such subdural hematomas can also be life-threatening, causing coma and death.

Most subdural hematomas are caused by severe head trauma sustained in automobile crashes.

But elderly people sometimes develop subdural hematomas after a very minor (and, therefore, often forgotten) head injury. As blood oozes into a closed space, the hematoma enlarges and begins to interfere with brain function.

Removing the clot within weeks of the injury may restore mental function. However, the symptoms often evolve so slowly that diagnosis is delayed for months.

Thyroid disease

An overproduction of thyroid hormones (hyperthyroidism) is commonly caused by Graves’ disease, while an underproduction (hypothyroidism) usually results from Hashimoto’s thyroiditis. Both disorders can cause dementia-like symptoms.

  • Hyperthyroidism. To diagnose hyperthyroidism, physicians use a simple blood test that measures levels of thyroid hormones. Surgically removing the thyroid or destroying it with radioactive iodine usually corrects the cognitive problems.
  • Hypothyroidism. This is diagnosed by measuring the level of thyroid-stimulating hormone circulating in the blood. Physicians usually recommend thyroid hormone replacement, but this treatment doesn’t always reverse the dementia.


Wernicke-Korsakoff syndrome, an irreversible state of confusion and amnesia in alcoholics, results from thiamine deficiency due to long-term malnutrition. But consuming excessive amounts of alcohol for a decade or more can also cause impaired thinking that resembles Alzheimer’s disease.

In dementia due to alcoholism, memory, orientation, and attention deteriorate, although verbal skills are not always severely affected. In this type of dementia, abstinence may partly restore mental functioning.

(Video) Are you TRAUMATISED? SYMPTOMS OF TRAUMA | Debunking DID: Ep 15 | DissociaDID | RE-UPLOAD

Irreversible dementias

Although there are many causes of irreversible dementia, the following conditions are among the most common. In some cases, prompt treatment can prevent further damage, but lost cognitive functioning cannot be restored.

Alzheimer’s disease

What’s Causing Your Memory Loss? - HelpGuide.org (3)

Alzheimer’s is distinguished from other dementias at autopsy by the presence of sticky beta-amyloid plaques outside brain cells (neurons) and fibrillary tangles within neurons. Although such lesions may be present in any aging brain, in people with Alzheimer’s these lesions tend to be more numerous and accumulate in areas of the brain involved in learning and memory.

The leading theory is that the damage to the brain results from inflammation and other biological changes that cause synaptic loss and malfunction, disrupting communication between brain cells. Eventually the brain cells die, causing tissue loss (see illustration). In imaging scans, brain shrinkage is usually first noticeable in the hippocampus, which plays a central role in memory function.

The hallmark symptom of Alzheimer’s is difficulty in recalling new information. As Alzheimer’s progresses, the following may occur:

  • Memory loss. This may be severe enough to disrupt daily life (for example, the person may get lost in a previously familiar neighborhood).
  • Cognitive decline. The individual may also experience decline in cognitive ability (finding it hard to make decisions, solve problems, or make good judgments).
  • Mood or personality changes. An individual with Alzheimer’s may undergo significant changes in mood and personality (such as becoming more irritable, hostile, or apathetic).

Alzheimer’s is severely debilitating, and death usually occurs within three to nine years after it is diagnosed. Five drugs have been approved for treating Alzheimer’s, but they alleviate symptoms only slightly.

Vascular dementia

Some cognitive problems stem from insufficient blood flow to portions of the brain. The decrease in blood flow is often the result of atherosclerosis (the accumulation of fatty deposits on artery walls) in the blood vessels that feed the brain. The resulting interruption of blood flow creates areas of dead tissue.

These events—which are in fact tiny strokes—often go unnoticed, because each one damages just a small part of the brain and doesn’t cause long-term impairment. But the cumulative damage can lead eventually to large areas of dead brain tissue, and symptoms such as confusion, impaired thinking, slurred speech, and paralysis may arise.

People with vascular dementia usually have one or more of the following risk factors:

  • hypertension (high blood pressure)
  • cardiovascular disease
  • diabetes
  • a history of stroke

The classic symptom of vascular dementia is an abrupt mental change, sometimes accompanied by paralysis or slurred speech. The mental deterioration proceeds in a “stairstep” pattern—a person suffers a sudden cognitive decline, the decline levels off, and then new strokes cause another sudden decline.

Degenerative diseases

Most dementias are caused by degenerative diseases, conditions whose deterioration cannot be stopped.
Alzheimer’s disease is the degenerative disease that is most often responsible for dementia, accounting for
more than 50% of cases. Frontotemporal lobar degeneration, Parkinson’s disease, and Huntington’s disease account for approximately 25% of all dementias.

Frontotemporal lobar degeneration. This group of diseases, formerly called Pick’s disease, is characterized by atrophy of the front part of the brain, including the frontal and temporal lobes. It is often confused with Alzheimer’s disease because the symptoms are sometimes identical. Some experts believe it may be the second most common dementia, after Alzheimer’s disease.

(Video) 10 Common Mental Illnesses Crash Course

The cause of frontotemporal lobar degeneration is unknown, but some variants can run in families, and it is sometimes associated with gene mutations. People with frontotemporal lobar degeneration exhibit symptoms such as:

  • prominent aphasia (impaired ability to use language) early in the illness
  • loss of inhibition, resulting in sociopathic or hypersexual behavior
  • loss of emotional responses such as fear
  • compulsively putting objects in their mouths.

Parkinson’s disease. This is a movement disorder resulting from a deficiency of dopamine, a neurotransmitter involved in coordinating muscle activity as well as memory function.

Its hallmarks include tremors, rigid limbs, and difficulty starting or stopping movement. Mild cognitive problems are common early in the disease, and dementia occurs in 30% to 80% of Parkinson’s patients in the late stages.

Some people with Parkinson’s disease develop dementia because they also have Alzheimer’s disease. In other cases, the dementia is associated with hallucinations and appears to be linked to damage in the limbic and cortical areas of the brain. This variant of Parkinson’s is called Lewy body dementia.

Drugs that increase dopamine transmission, such as levodopa (Sinemet), help control the physical symptoms of Parkinson’s but don’t improve mental function.

Huntington’s disease. Huntington’s disease is a rare inherited disorder linked to an abnormal gene on chromosome 4. Its symptoms include involuntary writhing movements and dementia, and they often begin between the ages of 20 and 40.

Mental disturbances may occur before or after physical problems appear, and people are often difficult to care for because of their irritability, aggressiveness, and erratic behavior. Medications can control the movement and mood disorders, but they don’t stop the disease from progressing.

Infectious dementias

Virtually any infectious agent that attacks the central nervous system can cause dementia.

Creutzfeldt-Jakob disease. This is a rare, rapidly progressive dementia caused by a type of infectious agent called a prion. The initial symptoms are fatigue and subtle changes in behavior. Typically, the disease progresses to movement problems, seizures, coma, and—within a year—death.

AIDS dementia. This form of dementia occurs in people with AIDS. The dementia can develop rapidly, sometimes in a matter of weeks, and consists of forgetfulness, inattentiveness, and thinking difficulties.

Neurosyphilis. Before the introduction of penicillin, up to 30% of dementia patients admitted to mental institutions had neurosyphilis. This disorder, which develops about 15 years after syphilis infection, is now rare, because syphilis is typically treated before it reaches that point.

Adapted with permission fromAlzheimer's Disease: A guide to diagnosis, treatment, and caregiving, a special health report published byHarvard Health Publishing.

Last updated or reviewed on February 23, 2023

(Video) Is it dementia or just forgetfulness - Positive Aging on the Learning Videos Channel


What’s Causing Your Memory Loss? - HelpGuide.org? ›

Two common examples are dementia caused by vitamin B12 deficiency or an underactive thyroid (hypothyroidism). Getting the right diagnosis is important so that you know what options you have, because symptoms subside when the underlying problem is treated.

What is the true cause of memory loss? ›

Many people worry about becoming forgetful. They think forgetfulness is the first sign of Alzheimer's disease. But not all people with memory problems have Alzheimer's. Other causes for memory problems can include aging, medical conditions, emotional problems, mild cognitive impairment, or another type of dementia.

What vitamin are you lacking for memory loss? ›

Vitamin B12 deficiency is linked to impaired cognition and memory along with a sensation of tingling and numbness, an outcome of poor myelination. Elevated methylmalonic acid and serum homocysteine levels are markers of Vitamin B12 deficiency.

What is the 5 word memory test? ›

Introduction: The five-word test (5WT) is a serial verbal memory test with semantic cuing. It is proposed to rapidly evaluate memory of aging people and has previously shown its sensitivity and its specificity in identifying patients with AD.

What is one of the first signs of cognitive decline? ›

You have trouble following a conversation. You find it hard to make decisions, finish a task or follow instructions. You start to have trouble finding your way around places you know well. You begin to have poor judgment.

What is the 3 word memory test? ›

The Mini-Cog test.

A third test, known as the Mini-Cog, takes 2 to 4 minutes to administer and involves asking patients to recall three words after drawing a picture of a clock. If a patient shows no difficulties recalling the words, it is inferred that he or she does not have dementia.

Can memory loss reversed? ›

Depression can mimic dementia, and appropriate treatment can reverse depression-related memory deficits. “Correcting these issues may help improve memory loss,” Dr. Parulekar says. On the other hand, memory loss resulting from brain disorders like Alzheimer's disease and dementia cannot be reversed.

What is the best natural vitamin for memory? ›

B Vitamins

“The vitamin B complex is crucial for supporting healthy brain function and may protect against memory loss, cognitive decline and neurodegenerative diseases,” says De Angelis.

What vitamin should I take to improve my memory? ›

Vitamin B12 is crucial for memory, so if you're deficient in it you could experience forgetfulness. A vitamin D deficiency could also put you at risk for memory-impairing conditions like Alzheimers. It's also important to make sure you're getting enough omega-3 fatty acids and vitamin E.

What is the best drug to improve memory? ›

Prescription smart drugs, such as Adderall and Ritalin, have the strongest and most significant effects on memory and attention. Synthetic nootropic supplements like Noopept and piracetam are widely available, but research on their effectiveness in healthy adults is lacking.

What are the 10 warning signs of dementia? ›

Ten warning signs of dementia
  • Dementia and memory loss. ...
  • Dementia and difficulty with tasks. ...
  • Dementia and disorientation. ...
  • Dementia and language problems. ...
  • Dementia and changes in abstract thinking. ...
  • Dementia and poor judgement. ...
  • Dementia and poor spatial skills. ...
  • Dementia and misplacing things.

What is the 5 minute dementia test? ›

The five-minute cognitive test (FCT) was designed to capture deficits in five domains of cognitive abilities, including episodic memory, language fluency, time orientation, visuospatial function, and executive function.

What are the first signs of dementia? ›

10 Early Signs and Symptoms of Alzheimer's and Dementia
  • Memory loss that disrupts daily life. ...
  • Challenges in planning or solving problems. ...
  • Difficulty completing familiar tasks. ...
  • Confusion with time or place. ...
  • Trouble understanding visual images and spatial relationships. ...
  • New problems with words in speaking or writing.

Why can't I remember things that just happened? ›

Severe stress, depression, a vitamin B12 deficiency, too little or too much sleep, some prescription drugs and infections can all play a role. Even if those factors don't explain your memory lapses, you don't need to simply resign yourself to memory loss as you age.

What are red flags of cognitive decline? ›

1. Memory loss that disrupts daily life: forgetting events, repeating yourself or relying on more aids to help you remember (like sticky notes or reminders). 2. Challenges in planning or solving problems: having trouble paying bills or cooking recipes you have used for years.

At what age does cognitive decline start? ›

“… relatively little decline in performance occurs until people are about 50 years old.” (Albert & Heaton, 1988). “… cognitive abilities generally remain stable throughout adult life until around age sixty.” (Plassman, et al., 1995)

What does a neurologist do for memory loss? ›

Behavioral neurologists specialize in cognitive problems such as memory loss, and are very good at detecting subtle brain injuries such as a small stroke or an infection that may be causing the memory problems. They also conduct very thorough neurological and cognitive exams.

At what age does memory start to decline? ›

Almost 40% of us will experience some form of memory loss after we turn 65 years old. But even if we experience memory loss, chances are still unlikely that we have dementia. For the most part, our memory loss is mild enough that we can still live our day-to-day lives without interruption.

Why can't I remember the most of my life? ›

Dissociative amnesia is a memory disorder. You can't remember information about your life. This may happen after you live through trauma or a stressful situation. A person with this condition has large gaps in their memory.


1. The 7 Stages of Alzheimer’s Disease
(Natural Cures)
2. How to Outsmart Stress After a Diagnosis of Mild Cognitive Impairment (MCI)
(Emory Brain Health Community Outreach)
3. Novena To Our Lady Of Perpetual Help | Memorare
(Meshie Beshie)
4. Signs Of Too Much Stress You Should Never Ignore
5. "Trouble sleeping" can be solved fast! - Memory Re-Framing
(Whole Life Whole Health)
6. Early Memory Loss Conference 2022 | Alzheimer’s LA
(Alzheimer's LA)
Top Articles
Latest Posts
Article information

Author: Manual Maggio

Last Updated: 01/10/2023

Views: 6083

Rating: 4.9 / 5 (69 voted)

Reviews: 92% of readers found this page helpful

Author information

Name: Manual Maggio

Birthday: 1998-01-20

Address: 359 Kelvin Stream, Lake Eldonview, MT 33517-1242

Phone: +577037762465

Job: Product Hospitality Supervisor

Hobby: Gardening, Web surfing, Video gaming, Amateur radio, Flag Football, Reading, Table tennis

Introduction: My name is Manual Maggio, I am a thankful, tender, adventurous, delightful, fantastic, proud, graceful person who loves writing and wants to share my knowledge and understanding with you.